Role of Inflammatory Mediators, Growth Factors, and Osteodystrophy in Recurrent Lumbar Disk Herniation

Introduction. Reintervention in patients with spinal disk herniation is shown to significantly decrease likelihood of favorable outcomes the postoperative period. Thus, it important individually assess risk factors for and recurrence each patient, choose a suitable surgical option.
 Objective: evaluate changes levels immunoregulatory mediators blood serum extracted disc tissue allegedly healthy individuals lumbar relapses.
 Materials methods. We examined 60 patients. The control group included 19 traumatic cord injuries at level. main 41 herniation. Twenty-two had primary while 11 presented single clinical neurological relapses pre-operated level 8 recurrent relapses. Solid-phase enzyme immunoassay detected proinflammatory cytokines (interleukin-6, tumor necrosis factor-), chemokines (interleukin-8, monocyte chemoattractant protein-1), growth (vascular endothelial factor, transforming factor-1), osteodestruction markers (osteoprogesterin, matrix metalloproteinase-8) tissue.
 Results. found that destruction chronic inflammation developed both locally generally elevating cytokines/chemokines, factors, metalloproteinase 8.
 Conclusion. results emphasize significance local studied parameters plan personalized treatment